基因名：
NCR3
产品别名：
1C7； CD337； LY117； MALS； NKp30； NCR3； natural cytotoxicity triggering receptor 3； natural cytotoxicity triggering receptor 3； natural cytotoxicity triggering receptor 3； NK-p30； activating NK-A1 receptor； activating natural killer receptor p30； lymphocyte antigen 117； natural killer cell p30-related protein； NKp30蛋白； 细胞毒性受体NK-p30； 自然细胞毒性触发受体3(NCR3)；
背景信息：
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed 'Natural Cytotoxicity Receptors'. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.
