基因名：
IFNL2
产品别名：
IFNL2a； IFNL3a； IL-28A； IL28A； IFNL2； interferon lambda 2； interferon lambda 2； interferon lambda-2； IFN-lambda-2； cytokine Zcyto20； interleukin 28A (interferon, lambda 2)； interleukin-28A； 白介素28A； 白介素28A(IL28A)； 白介素28A(IL28A)真核蛋白； 白细胞介素28A；
背景信息：
IL-28A (Interferon-λ2? IFN-λ2), IL-28B/IFN-λ3, and IL-29/IFN-λ1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines. Mature human IL-28A is an approximately 22-25 kDa protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration.
