TB-21007 is a nootropic drug which acts as a subtype-selective inverse agonist at the α5 containing GABAA receptors. TB-21007 impaired rats' memory of the initial shock-probe experience when infused into the dorsal hippocampus, but not when infused into the ventral hippocampus. References: McEown K, Treit D. Α2 GABAA receptor sub-units in the ventral hippocampus and α5 GABAA receptor sub-units in the dorsal hippocampus mediate anxiety and fear memory. Neuroscience. 2013 Nov 12;252:169-77. doi: 10.1016/j.neuroscience.2013.08.012. Epub 2013 Aug 17. PubMed PMID: 23962649.
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CAS:207306-50-1