GGTI 2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells. References: Yuan M, Gao S, Sun C, Chen L, Shi Q, Hu J, Yu R, Zhou X. Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system. Hippocampus. 2015 Mar;25(3):373-84. doi: 10.1002/hipo.22379. Epub 2014 Nov 25. PubMed PMID: 25330763.

纯度：≥98%

CAS：191102-87-1