Flavokawain B is a natural UCK2 inhibitor. It has been shown to bind to the cavity of R273H mutant p53 and restore wild-type p53 functions References: Malami I, Muhammad A, Etti IC, Waziri PM, Alhassan AM. An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53. EXCLI J. 2017 Dec 8;16:1276-1287. doi: 10.17179/excli2017-299. eCollection 2017. PubMed PMID: 29333130; PubMed Central PMCID: PMC5763090.
纯度:≥98%
CAS:1775-97-9