FFPM is a novel PDE4 inhibitor that has an IC50 of 26 nM and good selectivity over other PDEs. It may improve learning and memory abilities of patients. The drug also penetrates the blood–brain barrier well. References: Guo H, Cheng Y, Wang C, Wu J, Zou Z, Niu B, Yu H, Wang H, Xu J. FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects. Neuropharmacology. 2017 Apr;116:260-269. doi: 10.1016/j.neuropharm.2017.01.004. Epub 2017 Jan 6. PubMed
PMID: 28065587.
纯度:≥98%
CAS:1093412-18-0