Dirlotapide is a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor. This blocks the assembly and release of lipoproteins into the bloodstream, thereby reducing fat absorption. It also elicits a satiety signal from lipid-filled cells lining the intestine. Dirlotapide is a drug used to treat obesity in dogs. References: German AJ, Titcomb JM, Holden SL, Queau Y, Morris PJ, Biourge V. Cohort Study of the Success of Controlled Weight Loss Programs for Obese Dogs. J Vet Intern Med. 2015 Nov-Dec;29(6):1547-55. doi: 10.1111/jvim.13629. Epub 2015 Oct 1. PubMed PMID: 26426704; PubMed Central PMCID: PMC4895666.
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CAS:481658-94-0