Diphenyleneiodonium Chloride is an agonist of GPR3. It activates several GPR3-mediated signal transduction pathways, including Ca(2+) mobilization, cAMP accumulation, membrane recruitment of ss-arrestin2, and receptor desensitization. Diphenyleneiodonium Chloride also acts as a potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells, and inhibits other flavoenzymes such as neutrophil NADPH oxidase. References: Peng JJ, Liu B, Xu JY, Peng J, Luo XJ. NADPH oxidase: its potential role in promotion of pulmonary arterial hypertension. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):331-338. doi: 10.1007/s00210-017-1359-2. Epub 2017 Feb 11. Review. PubMed PMID: 28190244.

纯度：≥98%

CAS：4673-26-1