Delgocitinib(LEO124249 JTE052)

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CAS NO:	1263774-59-9
规格:	≥98%

包装与价格：

包装	价格(元)
1mg	询价
2mg	询价
5mg	询价
10mg	询价
25mg	询价

Delgocitinib (formerly LEO-124249; JTE052; LEO124249; JTE-052; Corectim) is a potent and selective JAK inhibitor with anti-inflammatory activities and has been approved in 2020 for use in Japan for the treatment of autoimmune disorders and hypersensitivity, including inflammatory skin conditions (e.g. atopic dermatitis). It inhibits JAK1, JAK2, JAK3 and Tyk2 with IC50s of 2.8, 2.6, 13 and 58 nM, respectively. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in Comparison with conventional therapeutic agents. JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation.

理化性质和储存条件

Molecular Formula: C16H18N6O;

Exact Mass: 310.1542
Molecular Weight: 310.361
Elemental Analysis: C, 61.92; H, 5.85; N, 27.08; O, 5.15

Related CAS #: 1263774-59-9 (free) 2064338-33-4 (EtOH) 2064338-35-6 (CHCl3)

Synonym: LEO-124249; JTE-052; LEO 124249; JTE 052; LEO124249; JTE052;

Chemical Name:3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile

InChi Key:LOWWYYZBZNSPDT-ZBEGNZNMSA-N

InChi Code:InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1

SMILES Code:N#CCC(N1C[C@H](C)[C@]12CN(C3=C4C(NC=C4)=NC=N3)CC2)=O