Dantrolene sodium is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. It is the primary drug used for the treatment and prevention of malignant hyperthermia, a rare, life-threatening disorder triggered by general anesthesia. It is also used in the management of neuroleptic malignant syndrome, muscle spasticity (e.g. after strokes, in paraplegia, cerebral palsy, or patients with multiple sclerosis), and 2,4-dinitrophenol poisoning. References: Nakamura K, Yoshizaki A, Saigusa R, Taniguchi T, Asano Y, Sato S. The efficacy of dantrolene sodium for muscle cramps in patients with localized scleroderma. J Eur Acad Dermatol Venereol. 2015 Nov 11. doi: 10.1111/jdv.13497. [Epub ahead of print] PubMed PMID: 26559172.

纯度：≥98%

CAS：7261-97-4