CP 115953 inhibits topoisomerase II activity via an interaction with the enzyme and not by DNA unwinding. CP 115953 stimulates cytokine production by lymphocytes. References: Bromberg KD, Burgin AB, Osheroff N. Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage. Biochemistry. 2003 Apr 1;42(12):3393-8. PubMed PMID: 12653542.
纯度:≥98%
CAS:136440-70-5