Cidofovir hydrate (HPMPC; Vistide) is a potent antiviral medication used as an injectable form for the treatment of cytomegalovirus (CMV) retinitis. It suppresses virus replication by selective inhibition of viral DNA synthesis. Cidofovir is an acyclic nucleoside phosphonate that has to be converted to cidofovir diphosphate which is incorporateed into viral DNA, selectively inhibiting CMV replication and CMV DNA synthesis with IC50 values of 0.1 μM. Cidofovir has significantly long-lasting antiviral action because of the long half-life of its metabolites whose cellular uptake is slow due to the presence of the negatively charged phosphonate group. Cidofovir has also exhibited high antitumor activity.

纯度：≥98%

CAS：149394-66-1