Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸，可激活 5'-三磷酸腺苷敏感的 K+ 通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂，可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin ) 相互作用并调节 IL-6/stat-3 通路。Guanosine 5'-diphosphate sodium 可用于炎症研究，如炎症性贫血 (AI)。
| Cas No. | 43139-22-6 |
| 别名 | GDP sodium |
| 分子式 | C10H15N5NaO11P2 |
| 分子量 | 466.19 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitiveK+channel. Guanosine 5'-diphosphate sodium is a potential iron mobilizer, which prevents thehepcidin-ferroportininteraction and modulates theinterleukin-6 (IL-6)/stat-3pathway. Guanosine 5'-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI)[1][2]. [1]. S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418.
[2]. Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097. |
