MFI8 是一种线粒体融合 (mitochondrial fusion) 的小分子抑制剂。
| Cas No. | 694488-83-0 |
| 分子式 | C16H18ClNO |
| 分子量 | 275.77 |
| 溶解度 | DMSO : 100 mg/mL (362.62 mM; Need ultrasonic) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MFI8 is a small molecule inhibitor ofmitochondrial fusion[1]. MFI8 (20 μM; 6 h) reduces significantly mitochondrial aspect ratio with an EC50of 4.8 μM, and inhibits mitochondrial fusion via mitofusins and subsequently promoting mitochondrial fission[1].
MFI8 possesses functional groups that meet the criteria of the pharmacophore model to interact with mitofusins and promotes mitochondrial fission[1].
MFI8 binds to the HR2 domain of MFN2, modulates MFN conformation and complexes, and alters mitochondrial functionality[1].
MFI8 (0-20 μM; 6 h) concentration-responsively increases caspase-3/7 activity, induces cytochrome c release and decreases membrane potential in a mitofusin-dependent manner. MFI8 also induces DNA damage and induces cell death in combination with BV6 SMAC (second mitochondria-derived activator of caspases) mimetic[1]. |
