UCB-5307 是一种 TNF 抑制剂，对人 TNFα 的 KD 为 9 nM。UCB-5307 可以穿透预制的 hTNF/hTNFR1 复合物。
| Cas No. | 1515887-44-1 |
| 分子式 | C22H21N3O |
| 分子量 | 343.42 |
| 溶解度 | DMSO : 50 mg/mL (145.59 mM; Need ultrasonic) |
| 储存条件 | 4°C, away from moisture and light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | UCB-5307 is a potentTNFsignaling inhibitor with aKDof 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex[1]. UCB-5307 inhibits wild-type TNF but does not inhibit L57F TNF. The T1/2of UCB-5307 is 3.3 h[1].
UCB-5307 disrupts a preformed hTNF/hTNFR1 complex, can penetrate the preformed complex, dislodging one of the receptors. Preloading hTNF with UCB-5307 blocks one receptor from binding[1].
UCB-5307 binds to a pocket in the centre of the TNF trimer formed by the movement of the TNF monomers, stabilising the distorted trimer, which leads to reduced signalling through TNFR1[1]. |
