BLM-IN-1 (compound 29) 是有效的、布鲁姆综合征蛋白 (BLM) 的抑制剂，对BLM的KD 值为1.81 μM，IC50 值为0.95 μM。可诱导DNA损伤反应，癌细胞的凋亡和增殖抑制。
| Cas No. | 2056014-40-3 |
| 分子式 | C28H35FN4O |
| 分子量 | 462.6 |
| 溶解度 | DMSO : 8.33 mg/mL (18.01 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BLM-IN-1 (compound 29) is an effective Bloom syndrome protein (BLM) inhibitor, with a strong BLM binding KD of 1.81 μM and an IC50 of 0.95 μM for BLM. Induces DNA damage response, as well as apoptosis and proliferation arrest in cancer cells[1]. [1]. Yin QK, et al. Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019 Mar 28;62(6):3147-3162. |
