HDAC-IN-40 是一种有效的基于烷氧基酰胺的 HDAC 抑制剂，对 HDAC2 和 HDAC6 的 Ki 值分别为 60 nM 和 30 nM。HDAC-IN-40 具有抗肿瘤作用。
| Cas No. | 2463198-51-6 |
| 分子式 | C15H22N2O6 |
| 分子量 | 326.34 |
| 溶解度 | DMSO : 250 mg/mL (766.07 mM; Need ultrasonic) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HDAC-IN-40 is a potent alkoxyamide-basedHDACinhibitor withKivalues of 60 nM and 30 nM forHDAC2andHDAC6, respectively. HDAC-IN-40 had antitumor effects[1]. HDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC50values of 0.89 µM and 0.72 µM, respectively[1].
HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR[1].
HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1]. |
