NN-390 是一种有效的选择性 HDAC6 抑制剂，IC50 为 9.8 nM。 NN-390 穿透血脑屏障 (BBB)。 NN-390 在转移性 3 MB 组（髓母细胞瘤）中显示出研究潜力。
| Cas No. | 2490284-25-6 |
| Canonical SMILES | O=C(C1=CC=C(CN(S(=O)(C2=CC(F)=C(C(F)=C2F)F)=O)C(C)C)C=C1)NO |
| 分子式 | C17H16F4N2O4S |
| 分子量 | 420.4 |
| 溶解度 | DMSO: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NN-390 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 9.8 nM).1It is selective for HDAC6 over HDAC3, HDAC8, and HDAC11 (IC50s = >1,000 nM for all). NN-390 is cytotoxic to MV4-11 leukemia, MM.1S multiple myeloma, and HD-MB03 medulloblastoma cells (IC50s = 1.19, 1.38, and 0.13 µM, respectively). 1.Nawar, N., Bukhari, S., Adile, A.A., et al.Discovery of HDAC6-selective inhibitor NN-390 with in vitro efficacy in group 3 medulloblastomaJ. Med. Chem.65(4)3193-3217(2022) |
