CVT-11127 是一种有效的 SCD 抑制剂。CVT-11127 诱导细胞凋亡 apoposis 并将细胞周期阻滞在 G1/S 期。 CVT-11127具有肺癌研究潜力。
| Cas No. | 1018674-83-3 |
| 别名 | GS-456332 |
| 分子式 | C25H23Cl2N5O3 |
| 分子量 | 512.39 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CVT-11127 is a potentSCDinhibitor. CVT-11127 inducesapoposisand arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1]. CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1]. Cell Proliferation Assay[1] | Cell Line: | H460 cells | | Concentration: | 1 µM | | Incubation Time: | 48 h | | Result: | Showed antiproliferation activity. |
Cell Cycle Analysis[1] | Cell Line: | H460 cells | | Concentration: | 1 µM | | Incubation Time: | 48 h | | Result: | Decreased the the population of cells in S-phase by 75%. |
Apoptosis Analysis[1] | Cell Line: | H460 cells | | Concentration: | 1 µM | | Incubation Time: | 24 h | | Result: | Induced apoposis H460 cells. |
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