B-Raf IN 10 (Compound C09) 是一种 BRAF 抑制剂，IC50 在 50-100 nM。B-Raf IN 10 具有抗肿瘤活性。
| Cas No. | 1425485-87-5 |
| 分子式 | C22H21F3N4O4S |
| 分子量 | 494.49 |
| 溶解度 | DMSO : 100 mg/mL (202.23 mM; ultrasonic and warming and heat to 60°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | B-Raf IN 10 (Compound C09) is aBRAFinhibitor with anIC50between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1]. B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1].
B-Raf IN 10 shows an IC50between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1].
B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1]. Cell Viability Assay[1] | Cell Line: | A375, SK-MEL-28, SK-MEL-31 and CHL-1 | | Concentration: | | | Incubation Time: | 72 h | | Result: | Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31. |
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