DDR1-IN-6 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC50 为 9.72 nM。DDR1-IN-6 抑制 DDR1b (Y513) 自磷酸化，IC50 为 9.7 nM。DDR1-IN-6 具有抗癌活性。
| Cas No. | 2416021-47-9 |
| 分子式 | C23H14F3N5O |
| 分子量 | 433.39 |
| 储存条件 | 4°C, away from moisture and light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DDR1-IN-6 is a selectiveDiscoidin Domain Receptor family, member 1 (DDR1)inhibitor with anIC50of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with anIC50of 9.7 nM. DDR1-IN-6 has anti-cancer activity[1]. DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=13 nM)[1].
DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC50=3 μM)[1].
DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC50=5.7 μM of 3 days; IC50=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC50>30 μM of 3 days; IC50>30 μM of 6 days)[1].
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