EGFR-IN-9 (化合物8) 是一种有效的 EGFR 激酶抑制剂，对于野生型 EGFR 激酶和双重突变型 EGFR 激酶 (L858R/T790M) 的 IC50 分别为 7 nM 和 28 nM。EGFR-IN-9 具有抗肿瘤活性。
| Cas No. | 1226549-39-8 |
| 分子式 | C29H24N4O3 |
| 分子量 | 476.53 |
| 溶解度 | DMSO : 100 mg/mL (209.85 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | EGFR-IN-9 (Compound 8) is a potentEGFR kinaseinhibitor withIC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity[1]. EGFR-IN-9 (Compound 8) shows antiproliferative activity in HCC827 lung cancer cell line with an IC50of 8 nM. |
