MOMIPP，一种巨胞饮作用的诱导剂，是一种 PIKfyve 抑制剂。MOMIPP 可穿过血脑屏障 (BBB)。
| Cas No. | 1363421-46-8 |
| 分子式 | C18H16N2O2 |
| 分子量 | 292.33 |
| 溶解度 | DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MOMIPP, a macropinocytosis inducer, is aPIKfyveinhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2]. MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations[1].
In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[2]. Western Blot Analysis[2] | Cell Line: | U251 cells | | Concentration: | 10 μM | | Incubation Time: | 4 h or 24 h | | Result: | Activated the JNK stress kinase pathway. |
MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts[2]. | Animal Model: | Athymic CrTac:NCR-Foxn1mice (female, 7-8 weeks)[2] | | Dosage: | 80 mg/kg | | Administration: | i.p.; once daily; for 15 consecutive days | | Result: | Suppressed progression of intracerebral glioblastoma xenografts. |
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