| CAS NO: | 2230820-11-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 询价 |
| 5mg | 询价 |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| 250mg | 询价 |
| Cas No. | 2230820-11-6 |
| 分子式 | C18H20N8O2 |
| 分子量 | 380.4 |
| 溶解度 | DMSO : 5 mg/mL (13.14 mM; ultrasonic and warming and heat to 80°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity[1]. AZD7648 (0-30 μM) is a potent radiosensitizer[1].AZD7648 (3 μM) increases sensitivity to doxorubicin[1].AZD7648 (0.6 μM) enhances the activity of PARP inhibitor olaparib[1]. AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression[1]. [1]. Fok JHL, et al. AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat Commun. 2019 Nov 7;10(1):5065. |
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