(32-Carbonyl)-RMC-5552 是一种有效的 mTOR 抑制剂。(32-Carbonyl)-RMC-5552 抑制 mTORC1 和 mTORC2 底物 (p-P70S6K-(T389)、p-4E-BP1-(T37/36) 和 p-AKT1/2/3-(S473)) 磷酸化 pIC50s 分别为 >9, >9, 以及 8-9 之间 (专利 WO2019212990A1, example 2)。
| Cas No. | 2382768-55-8 |
| 分子式 | C93H134N10O24 |
| 分子量 | 1776.11 |
| 溶解度 | DMSO : 146.67 mg/mL (82.58 mM; Need ultrasonic) |
| 储存条件 | 4°C, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of >9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1]. [1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1. |
