Estramustine 是一种抗肿瘤剂。Estramustine 通过与微管蛋白 1 (tubulin 1)结合来解聚微管，具有抗有丝分裂活性，对 DU 145 细胞有丝分裂的 IC50 大约为 16 μM。Estramustine 在前列腺肿瘤异种移植模型中阻断前列腺肿瘤细胞有丝分裂。
| Cas No. | 2998-57-4 |
| 分子式 | C23H31Cl2NO3 |
| 分子量 | 440.4 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding totubulin 1, exhibits antimitotic activity with anIC50value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1]. [1]. DahllÖf B, et al. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res. 1993 Oct 1;53(19):4573-81. |
