BLU-945 是一种有效的选择性表皮生长因子受体 (EGFR) 抑制剂。EGFR是erbB受体家族的成员，该家族包括跨膜蛋白酪氨酸激酶受体。BLU-945 有效抑制具有 L858R 和/或外显子 19 缺失突变、T790M 突变和 C797S 突变的 EGFR。BLU-945 有助于有效给药并降低 EGFR 介导的靶向毒性。BLU-945 具有研究癌症疾病的潜力 (信息提取自专利 WO2021133809A1，化合物 112)。
| Cas No. | 2660250-10-0 |
| 别名 | 蓝-945 |
| 分子式 | C28H37FN6O3S |
| 分子量 | 556.7 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | receptor (EGFR). EGFR is a member of the erbB receptor family, which includes transmembrane protein tyrosine kinase receptors. BLU-945 effectively inhibits EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation. BLU-945 facilitates efficacious dosing and reduces EGFR-mediated on-target toxicities. S BLU-945 has the potential for the research of cancer disease (extracted from patent WO2021133809A1, compound 112)[1]. [1]. John Emmerson Campbell, et al. Inhibitors of mutant forms of egfr. Patent WO2021133809A1. |
