An internal standard for the quantification of apatinib
| Cas No. | 2468771-43-7 |
| Canonical SMILES | O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC=C(C4(C#N)C([2H])([2H])C([2H])([2H])C([2H])([2H])C4([2H])[2H])C=C3 |
| 分子式 | C24H15D8N5O |
| 分子量 | 405.5 |
| 溶解度 | DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Apatinib-d8is intended for use as an internal standard for the quantification of apatinib by GC- or LC-MS. Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2; IC50= 1 nM).1It is less effective against c-Kit (IC50= 429 nM), RET (IC50= 13 nM), and c-Src (IC50= 53 nM) and does not inhibit EGFR, HER2, or FGFR1 (IC50s = >10 µM).1Apatinib has been shown to inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) stimulated by fetal bovine serum and, either alone or in combination with chemotherapeutic agents, prevents the growth of several established human tumor xenograft models.1 1.Tian, S., Quan, H., Xie, C., et al.YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivoCancer Sci.102(7)1374-1380(2011) |
