TAK-020 是一种Btk共价抑制剂，成为临床候选药物。
| Cas No. | 1627603-21-7 |
| 分子式 | C18H17N5O3 |
| 分子量 | 351.36 |
| 溶解度 | DMSO : 16.67 mg/mL (47.44 mM; ultrasonic and warming and heat to 60℃) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate. [1]. Sabat M, et al. Discovery of the Bruton’s Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64(17):12893-12902. |
