5-HT3 antagonist 5 是一种喹喔啉 -2- 甲酰胺化合物，是 5-HT3 受体拮抗剂。5-HT3 antagonist 5 对 5-HT3 激动剂和 2- 甲基 -5-HT 也具有拮抗作用，并在小鼠中表现出抗抑郁效果。
| Cas No. | 901599-43-7 |
| 分子式 | C16H13N3O2 |
| 分子量 | 279.29 |
| 溶解度 | DMSO : 20.83 mg/mL (74.58 mM; ultrasonic and warming and heat to 60°C) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a5-HT3receptorantagonist. 5-HT3 antagonist 5 exerts antagonism on5-HT3agonist and2-methyl-5-HT, and shows anti-depressant effect in mice[1]. 5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3agonist, 2-methyl-5-HT, with pA2value of 5[1].
5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice[1].
| Animal Model: | Swiss albino mice (23 ± 2 g)[1] | | Dosage: | 1 mg/kg | | Administration: | Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration | | Result: | Reduced the duration of immobility as compared to the vehicle-treated (control) group.
Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity. |
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