Wnt/β-catenin agonist 3 (compound 98) 是一种 Wnt/β-catenin 信号通路激动剂。Wnt/β-catenin agonist 3 可用于骨质疏松症的研究。
| Cas No. | 912790-59-1 |
| 分子式 | C16H15ClN4O2 |
| 分子量 | 330.77 |
| 溶解度 | DMSO : 250 mg/mL (755.81 mM; Need ultrasonic) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Wnt/β-catenin agonist 3 (compound 98) is aWnt/β-cateninsignalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis[1]. Wnt/β-catenin agonist 3 (compound 98; 24 h; HEK293 and SW480 cells) has 54% cell activity at 120 μM concentration compared with the positive control group LiCl (20mM)[1].
Wnt/β-catenin agonist 3 (30 and 60 μM; 24 h; HEK293 cells) is an activator for β-Catenin and deposits β-catenin[1].
Wnt/β-catenin agonist 3 (11 μM; 4 d) induces differentiation of ST2 cell line into osteoblasts and calcium deposition[1]. Western Blot Analysis[1] | Cell Line: | HEK293 cells | | Concentration: | 30 and 60 μM | | Incubation Time: | 24 hours | | Result: | Deposited β-catenin in a dose-dependent pattern within cells. |
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