| CAS NO: | 2438637-61-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 询价 |
| 1mg | 询价 |
| 5mg | 询价 |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| Cas No. | 2438637-61-5 |
| 分子式 | C23H17Cl2F3N2O4S |
| 分子量 | 545.36 |
| 溶解度 | DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1]. NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells[1]. [1]. Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March. |
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