A metabolite of prednisolone
| Cas No. | 16355-29-6 |
| 别名 | 泼尼松龙杂质D |
| Canonical SMILES | C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C([C@@H](C3)O)=CC(C=C4)=O)C |
| 分子式 | C21H28O6 |
| 分子量 | 376.4 |
| 溶解度 | DMSO: soluble,Methanol: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 6β-hydroxy Prednisolone is a metabolite of prednisolone , the active metabolite of prednisone .1It is formed from prednisolone primarily by the cytochrome P450 (CYP) isoform CYP3A4 and to a lesser extent by CYP3A5. 1.Skauby, R.H., Bergan, S., Andersen, A.M., et al.In vitro assessments predict that CYP3A4 contributes to a greater extent than CYP3A5 to prednisolone clearanceBasic Clin. Pharmacol. Toxicol.129(6)427-436(2021) |
