A corticosteroid metabolite of 11-keto progesterone
| Cas No. | 1882-82-2 |
| 别名 | 17α-羟基孕甾-4-烯-3,11,20-三酮 |
| Canonical SMILES | C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4(C(CC3)=CC(CC4)=O)C |
| 分子式 | C21H28O4 |
| 分子量 | 344.5 |
| 溶解度 | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol |
| 储存条件 | -20буC |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 21-Deoxycortisone is a corticosteroid metabolite of 11-keto progesterone.1It is formed from 11-keto progesterone by the cytochrome P450 (CYP) isoform CYP17A1, but can also be producedviaoxidation of 21-deoxycortisol by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Levels of 21-deoxycortisone are increased in patients with congenital adrenal hyperplasia, an inborn error of metabolism characterized by a deficiency in 21-hydroxylase.2 1.van Rooyen, D., Yadav, R., Scott, E.E., et al.CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathwayJ. Steroid Biochem. Mol. Biol.199105614(2020)
2.Saisho, S., Shimozawa, K., and Yata, J.Changes of several adrenal δ4-steroids measured by HPLC-UV spectrometry in neonatal patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiencyHorm. Res.33(1)27-34(1990) |
