An estrogen receptor antagonist and a derivative of fulvestrant
| Cas No. | 98008-06-1 |
| 别名 | 氟维司群-9-砜 |
| Canonical SMILES | OC1=CC=C2C(C[C@@H](CCCCCCCCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=C1 |
| 分子式 | C32H47F5O4S |
| 分子量 | 622.8 |
| 溶解度 | DMSO: slightly soluble,Methanol: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fulvestrant 9-sulfone is an estrogen receptor antagonist and a derivative of the selective estrogen receptor degrader (SERD) fulvestrant .1It binds to estrogen receptor α (ERα) and ERβ and inhibits estrogen-induced gene expression in a reporter assay in Ishikawa endometrial cells expressing an estrogen response element (ERE) reporter when used at concentrations ranging from 0.1 to 100 µM. 1.Nuttall, M.E., Pendrak, I., Emery, J.G., et al.Antagonism of oestrogen action in human breast and endometrial cells in vitro: Potential novel antitumour agentsCancer Chemother. Pharmacol.47(5)437-443(2001) |
