1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC is a lysophospholipid containing docosahexaenoic acid at thesn-1 position that has been found in shark liver extract.¹1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC decreases LPS-induced increases in TNF-α and IL-6 levels in RAW 264.7 cells in a concentration-dependent manner.²It decreases LPS-induced production of nitric oxide (NO) in RAW 264.7 cells when used at concentrations ranging from 12 to 200 µM. 1-Docosahexaenoyl-2-hydroxy-sn-glycero-3-PC (15-500 µg/kg) inhibits plasma leakage into the peritoneum in a mouse model of peritonitis induced by zymosan A .

1.Chen, S., and Li, K.W.Mass spectrometric identification of molecular species of phosphatidylcholine and lysophosphatidylcholine extracted from shark liverJ. Agric. Food Chem.55(23)9670-9677(2007) 2.Huang, L.S., Hung, N.D., Sok, D.-E., et al.Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatoryLipids45(3)225-236(2010)