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Tesofensine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tesofensine图片
CAS NO:195875-84-4
包装与价格:
包装价格(元)
5mg询价
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Tesofensine (NS-2330) 是一种三元单胺再摄取抑制剂,可有效抑制神经递质多巴胺 (DA; IC50=6.5 nM)、去甲肾上腺素 (NE;IC50=1.7 nM) 和5-羟色胺 (5-HT;IC50=11 nM),具有作为抗肥胖剂的潜力。
Cas No.195875-84-4
别名特索芬辛,NS-2330
Canonical SMILESCN1[C@@H]2C[C@H](C3=CC(Cl)=C(Cl)C=C3)[C@@H](COCC)[C@H]1CC2
分子式C17H23Cl2NO
分子量328.3
溶解度DMF: 2 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.14 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tesofensine is a triple monoamine reuptake inhibitor that inhibits norepinephrine, serotonin (5-HT), and dopamine reuptake function.1,2In vivo, tesofensine (2 mg/kg, s.c.) reduces body weight and food intake in a rat model of high-fat diet-induced obesity.1

1.Axel, A., M,D., Mikkelsen, J.D., and Hansen, H.H.Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of α1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese ratNeuropsychopharmacology35(7)1464-1476(2010) 2.van de Giessen, E., de Bruin, K., la Fleur, S.E., et al.Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese ratsEur. Neuropsychopharmacol.22(4)290-299(2012)

 
 
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