AMG 333是有效，高选择性的 TRPM8 拮抗剂，IC50为13 nM。
| Cas No. | 1416799-28-4 |
| 分子式 | C20H12F5N3O4 |
| 分子量 | 453.32 |
| 溶解度 | DMSO : ≥ 125 mg/mL (275.74 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. [1]. Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201. |
