Flecainide 是一种有效的具有口服活性的抗心律失常剂。Flecainide 阻断心脏快速内向 Na+ 电流 (INa) 和延迟整流器 K+ 电流的快速成分。Flecainide 可延长心室和心房肌纤维的动作电位持续时间 (APD)。Flecainide 具有研究胎儿心动过速的潜力。
| Cas No. | 54143-55-4 |
| 别名 | 氟卡尼 |
| 分子式 | C17H20F6N2O3 |
| 分子量 | 414.34 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Flecainide is a potent and orally active antiarrhythmic agent. Flecainide blocks the cardiac fast inward Na+ current (INa) and the rapid component of the delayed rectifier K+ current. Flecainide prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide has the potential for the research of fetal tachycardias[1][2][3]. [1]. Echt DS, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991 Mar 21;324(12):781-8.
[2]. Aliot E, et al. Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation. Europace. 2011 Feb;13(2):161-73.
[3]. Allan LD, et al. Flecainide in the treatment of fetal tachycardias. Br Heart J. 1991 Jan;65(1):46-8. |
