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Ras Inhibitory Peptide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:159088-48-9
包装与价格：
包装价格(元)
500μg询价
1mg询价
5mg询价
10mg询价

Cas No.159088-48-9
Canonical SMILES[H]N[C@@H](C(C)C)C(N1CCC[C@H]1C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@@H](C(C)C)C(N4CCC[C@H]4C(N5CCC[C@H]5C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
分子式C53H91N19O11
分子量1170.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: Miscible,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.

 
 
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