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pm26TGF-⓵ peptide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
5mg询价
10mg询价
50mg询价

pm26TGF-β1 peptide 是一种模拟人 TGF-β1 分子的肽，并对 TGF-β1 受体具有高亲和力。pm26TGF-β1 peptide 具有有效的抗炎特性，并且不表现出嗜中性粒细胞的趋化性。
分子式C54H93N19O20S2
分子量1392.56
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction[1][2].

The synthetic pm26TGF-β1 peptide (1 μM, 10 μM and 100 μM; 24-48 hours) tested in peripheral blood mononuclear cells (PBMC) significantly down-modulates TNF-α and up-regulates IL-10 responses in an inflammatory microenvironment, leading to regulatory T cells (Treg) phenotype differentiation[1].

pm26TGF-β1 peptide (100-1000 µg/kg; subcutaneous injection; once; male C57BL/6 mice) treatment decreases neutrophils migration during inflammatory process in C57BL/6 mice[1].

[1]. EmÍlia R Vaz, et al. A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity. PLoS One. 2015 Aug 27;10(8):e0136116.
[2]. Rodrigues, Tamiris Sabrina. Evaluation of the action of the synthetic peptide pm26TGF-β1, human TGF-β1 mimetic, on TNF-α induced apoptosis in Drosophila melanogaster. Universidade Federal de UberlÂndia, 2017.

 
 
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