β,β-Dimethylacrylshikonin 是从 Arnebia nobilis 中提取得到的一种萘醌衍生物，通过PI3K通路诱导 eNOS、VEGF 和 HIF-1α 的表达，促进血管生成。Arnebin 1 具有抗肿瘤活性。
| Cas No. | 24502-79-2 |
| 别名 | (β,β-二甲基丙烯酰基)紫草素,Isoarnebin I |
| Canonical SMILES | O=C1C2=C(O)C=CC(O)=C2C(C=C1[C@@H](C/C=C(C)/C)OC(/C=C(C)/C)=O)=O |
| 分子式 | C21H22O6 |
| 分子量 | 370.4 |
| 溶解度 | DMSO: 25 mg/mL (67.49 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | β,β-Dimethylacrylshikonin is a naphthoquinone derivative isolated from Arnebia nobilis, promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Arnebin 1 has anti-tumor activity[1]. [1]. Zeng Z, et al. Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Int J Mol Med. 2015 Sep;36(3):685-97.
[2]. Sidhu GS, et al. Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing. J Invest Dermatol. 1999 Nov;113(5):773-81. |
