产品描述 | ε-Rhodomycinone is a bacterial metabolite that has been found inS. griseoruber.1It is a precursor to rhodomycin D, which is an intermediate in the bioconversion of ε-rhodomycinone to daunorubicin and doxorubicin .2,3 1.Podojil, M., BlumauerovÁ, M., P?ikrylovÁ, V., et al.Production of rhodomycins in Streptomyces griseoruber 4620Folia Microbiol. (Praha)25(6)464-466(1980)
2.Olano, C., Lomovskaya, N., Fonstein, L., et al.A two-plasmid system for the glycosylation of polyketide antibiotics: Bioconversion of ε-rhodomycinone to rhodomycin DChem. Biol.6(12)845-855(1999)
3.Dickens, M.L., Priestley, N.D., and Strohl, W.R.In vivo and in vitro bioconversion of ε-rhodomycinone glycoside to doxorubicin: Functions of DauP, DauK, and DoxAJ. Bacteriol.179(8)2641-2650(1997) |