(R)-Pirtobrutinib 是活性较差的 Pirtobrutinib 异构体。Pirtobrutinib 是一种高选择性和非共价的下一代 BTK 抑制剂，可抑制多种 BTK C481 替代突变。
| Cas No. | 2101700-14-3 |
| 别名 | (R)-LOXO-305 |
| 分子式 | C22H21F4N5O3 |
| 分子量 | 479.43 |
| 溶解度 | DMSO : 200 mg/mL (417.16 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib. Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations[1]. [1]. Gomez E B , et al. Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations[J]. Blood, 2019, 134(Supplement_1):4644-4644. |
