| CAS NO: | 914800-65-0 |
| 包装: | 1mg |
| 市场价: | 2786元 |
| Cas No. | 914800-65-0 |
| Canonical SMILES | O=C1C2=C(NC(N)=N1)NCC(N2)CN(C3=CC=C(C=C3)C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=O.[Na+].[Na+] |
| 分子式 | C20H21N7O7 • 2Na |
| 分子量 | 517.4 |
| 溶解度 | Methanol: slightly soluble,Water: slightly soluble |
| 储存条件 | -80°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 10-Formyltetrahydrofolate is a formyl donor and cofactor, as well as a metabolite of 5,10-methylenetetrahydrofolic acid .1It is formed from 5,10-methylenetetrahydrofolic acid by methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) in the cytosol and MTHFD2 and MTHFD2L in the mitochondria. 10-Formyltetrahydrofolate provides the formyl group for conjugation to methionine-tRNA, which is required for mitochondrial protein translation initiation, and is also involved in purine biosynthesis.2,3 1.Li, A.M., and Ye, J.Reprogramming of serine, glycine and one-carbon metabolism in cancerBiochim. Biophys. Acta Mol. Basis Dis.1866(10)165841(2020) 2.Minton, D.R., Nam, M., McLaughlin, D.J., et al.Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAsMol. Cell69(4)610-621(2018) 3.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide biosynthesisBiochemistry(2002) |
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