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C18 Ganglioside GD3-d3(ammonium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
C18 Ganglioside GD3-d3(ammonium salt)图片
CAS NO:2692624-24-9
包装:500 µg
市场价:8330元

An internal standard for the quantification of ganglioside GD3
Cas No.2692624-24-9
Canonical SMILESOC[C@H]1O[C@@H](OC[C@H](NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@H](O)[C@@H](O)[C@@H]1O[C@]2([H])O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O[C@@]4(C([O-])=O)O[C@@H]([C@H](O)[C@@H](CO)O)[C@H](NC(C)=O)[C@@H](O)C4)CO)[C@H](NC(C)=O)[C@@H](O)C3)[C@H]2O.[NH4+].[NH4+]
分子式C70H120D3N3O29 • 2NH4
分子量1509.8
溶解度Chloroform:Methanol:Water (2:1:0.1): Soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

C18 Ganglioside GD3-d3is intended for use as an internal standard in the quantification of ganglioside GD3by GC- or LC-MS. Ganglioside GD3is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer.1Furthermore, the intracellular accumulation of ganglioside GD3can contribute to mitochondrial damage, a crucial event during apoptosis.2Ganglioside GD3has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.1,3[Matreya, LLC. Catalog No. 2054]

1.Hamamura, K., Furukawa, K., Hayashi, T., et al.Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cellsProc. Natl. Acad. Sci. USA102(31)11041-11046(2005) 2.De Maria, R., Lenti, L., Malisan, F., et al.Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosisScience277(5332)1652-1655(1997) 3.Nicoll, G., Avril, T., Lock, K., et al.Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanismsEur. J. Immunol.33(6)1642-1648(2003)

 
 
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