BM-1244 是一种有效的 Bcl-xL/Bcl-2 抑制剂，对 Bcl-xL 和 Bcl-2 的Ki 分别为 134 和 450 nM。BM-1244 抑制衰老成纤维细胞 (SnCs)，EC50 为 5 nM。
| Cas No. | 1619923-32-8 |
| 别名 | APG-1252-M1 |
| 分子式 | C54H59ClF4N6O8S4 |
| 分子量 | 1159.79 |
| 溶解度 | DMSO : 200 mg/mL (172.45 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1]. [1]. Jill Hopkins, et al. Treatment of ophthalmic conditions such as macular degeneration, glaucoma, and diabetic retinopathy using pharmaceutical agents that eliminate senescent cells. WO2019033119A1.
[2]. Kim R. Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun. 2005;333(2):336-343. |
