| 产品描述 | Hydroxy celecoxib is an inactive metabolite of celecoxib .1It is formed from celecoxib by the cytochrome P450 (CYP) isoforms CYP2C9, CYP3A4, and CYP2D6 in human liver microsomes.2 1.Penning, T.D., Talley, J.J., Bertenshaw, S.R., et al.Synthesis and biological evaluation fo the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib)J. Med. Chem.40(9)1347-1365(1997)
2.Siu, Y.A., Hao, M.-H., Dixit, V., et al.Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variantsDrug Metab. Pharmacokinet.33(5)219-227(2018) |
