M1001 是一种较弱的 HIF-2α 激动剂，直接与 HIF-2α PAS-B 结构域结合，Kd 值为 667 nM。M1001 能够增强 HIF-2α-ARNT 复合体之间的稳定性。
| Cas No. | 874590-32-6 |
| 分子式 | C17H17N3O2S |
| 分子量 | 327.4 |
| 溶解度 | DMSO : 250 mg/mL (763.59 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | M1001 is a weak agonist of HIF-2α, directly binds to the HIF-2α PAS-B domain, with a Kd of 667 nM. M1001 enhances the stabilities of HIF-2α-ARNT complex[1]. [1]. Wu D, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Feb 25. |
