Elevenostat (JB3-22) 是一种选择性 HDAC11 抑制剂 (IC50=0.235 µM)。抗多发性骨髓瘤 (MM) 活性。
| Cas No. | 1454902-97-6 |
| 别名 | JB3-22 |
| 分子式 | C16H17N3O4 |
| 分子量 | 315.32 |
| 溶解度 | DMSO : 250 mg/mL (792.85 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Elevenostat (JB3-22) is a selective HDAC11 inhibitor (IC50=0.235 µM). Anti-multiple myeloma (MM) activity[1]. [1]. Huang J, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7(1):8626. Published 2017 Aug 17.
[2]. Mostofa A, et al. Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma. JCI Insight. 2021;6(24):e151713. Published 2021 Dec 22. |
